Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 13/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 10/20 | 0.52 |
| ▸ | PLK2 | Q9NYY3 | 9/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCND2 | P30279 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | TAF1 | P21675 | 2/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784208 | 0.91 | PLK1 (0.52) | PLK1PLK3PLK2MAPK7BRD4 | |
| SCHEMBL4729390 | 0.89 | PLK1 (0.56) | PLK1PLK3PLK2MAPK7DYRK1A | |
| SCHEMBL4784197 | 0.89 | PLK1 (0.56) | PLK1PLK3PLK2CDK4CCND1 | |
| SCHEMBL4783060 | 0.88 | PLK1 (0.49) | PLK1PLK3PLK2MAPK7DYRK1A | |
| SCHEMBL4729386 | 0.87 | PLK1 (0.53) | PLK1PLK3PLK2MAPK7DYRK1A | |
| SCHEMBL14221001 | 0.87 | PLK1 (0.54) | PLK1PLK3PLK2MAPK7DYRK1A | |
| SCHEMBL4781952 | 0.86 | CDK4 (0.53) | PLK1PLK3PLK2CDK4CCND1 | |
| SCHEMBL4782067 | 0.86 | PLK1 (0.52) | PLK1PLK3PLK2MAPK7DYRK1A | |
| SCHEMBL4782475 | 0.86 | PLK1 (0.54) | PLK1PLK3PLK2MAPK7DYRK1A | |
| SCHEMBL4782801 | 0.85 | PLK1 (0.53) | PLK1PLK3PLK2MAPK7DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |