Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 9/20 | 0.85 |
| ▸ | KDR | P35968 | 11/20 | 0.61 |
| ▸ | FLT1 | P17948 | 8/20 | 0.61 |
| ▸ | KIT | P10721 | 5/20 | 0.61 |
| ▸ | FLT4 | P35916 | 5/20 | 0.61 |
| ▸ | CSF1R | P07333 | 5/20 | 0.60 |
| ▸ | FLT3 | P36888 | 5/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.60 |
| ▸ | LCK | P06239 | 4/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 4/20 | 0.57 |
| ▸ | RET | P07949 | 4/20 | 0.57 |
| ▸ | GSK3B | P49841 | 4/20 | 0.57 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.57 |
| ▸ | GSK3A | P49840 | 3/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800594 | 0.92 | TEK (1.00) | TEKKDRFLT1KITFLT4 | |
| SCHEMBL4796015 | 0.84 | TEK (0.86) | TEKKDRFLT1KITFLT4 | |
| SCHEMBL4467818 | 0.81 | TEK (0.83) | TEKKDRFLT1KITFLT4 | |
| SCHEMBL4796059 | 0.77 | TEK (1.00) | TEKKDRFLT1KITFLT4 | |
| SCHEMBL4800669 | 0.77 | TEK (0.72) | TEKKDRFLT1KITFLT4 | |
| SCHEMBL4480247 | 0.77 | TEK (0.85) | TEKKDRFLT1KITFLT4 | |
| SCHEMBL4483938 | 0.76 | KDR (1.00) | TEKKDRFLT1KITFLT4 | |
| SCHEMBL4806052 | 0.76 | TEK (0.79) | TEKKDRFLT1KITFGFR1 | |
| SCHEMBL4471994 | 0.75 | TEK (0.85) | TEKKDRFLT1KITFLT4 | |
| SCHEMBL4466103 | 0.75 | KDR (1.00) | TEKKDRFLT1KITFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427616-B2 | Condensed pyridines and pyrimidines with tie2 (TEK) activity | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | claimed |
| EP-1537112-B1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | claimed |
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | claimed |
| US-7427616-B2 | Condensed pyridines and pyrimidines with tie2 (TEK) activity | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | disclosed |
| EP-1537112-B1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | TIE1, TEK, KDR | TEK 2/4885KDR 3/4885FLT1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.