Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | USP2 | O75604 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4803502 | 0.84 | MAP4K4 (0.65) | MAPK10CNR1MAPKAPK2MAP4K4MAPK8 | |
| SCHEMBL4066872 | 0.77 | PIK3CA (0.62) | CYP1A2CYP3A4USP2CYP2C19CLK4 | |
| SCHEMBL22259649 | 0.77 | HPGD (0.53) | CYP1A2CYP3A4CYP2C19CLK4CYP2C9 | |
| SCHEMBL14254321 | 0.72 | MAPK10 (0.53) | CYP1A2CLK4CYP2C9MAPK10MAPK9 | |
| SCHEMBL4541615 | 0.72 | MAPKAPK2 (0.54) | CNR1MAPKAPK2GRM5 | |
| SCHEMBL3630523 | 0.72 | ALDH1A1 (0.59) | CYP1A2CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL21312135 | 0.71 | MAPK10 (0.64) | USP2MAPK10MAPKAPK2LMNAALDH1A1 | |
| SCHEMBL3512536 | 0.70 | CYP1A2 (0.55) | CYP1A2CLK4CYP2C9MAPK10MAPK9 | |
| SCHEMBL8351036 | 0.69 | MAPK8 (0.66) | MAPK10LMNAMAPK8 | |
| SCHEMBL1518709 | 0.69 | RECQL (0.52) | CYP1A2CLK4CYP2C9MAPK10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |