Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.44 |
| ▸ | KDM5C | P41229 | 4/20 | 0.44 |
| ▸ | KDM6B | O15054 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL4803416 | 0.92 | ALDH1A1 (0.56) | ALDH1A1EGLN1LMNAALKBH5SUCNR1 | |
| SCHEMBL61972 | 0.88 | — | — | |
| SCHEMBL28308084 | 0.88 | ALDH1A1 (0.64) | ALDH1A1EGLN1LMNAALKBH5SUCNR1 | |
| Sebacic Acid SCHEMBL7798552 | 0.86 | ALDH1A1 (0.86) | ALDH1A1LMNATSHROR51E2SLC22A6 | |
| Butyric Acid SCHEMBL2256290 | 0.86 | FFAR3 (0.68) | ALDH1A1TSHRFFAR3HDAC3HDAC1 | |
| SCHEMBL407967 | 0.85 | ALDH1A1 (0.50) | ALDH1A1EGLN1LMNAALKBH5SUCNR1 | |
| SCHEMBL1278771 | 0.85 | — | — | |
| SCHEMBL6559475 | 0.85 | — | — | |
| SCHEMBL2771851 | 0.85 | — | — | |
| Phosphine SCHEMBL22638904 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452654-B2 | Toner production method and toner production apparatus | KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) | 2008-11-18 | — | — | US | disclosed |
| US-20060160012-A1 | Toner production method and toner production apparatus | KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. | 2006-07-20 | — | — | US | disclosed |