Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 18/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | WNT3 | P56703 | 5/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781291 | 0.92 | SFRP1 (0.52) | SFRP1LMNAWNT3 | |
| SCHEMBL4736342 | 0.91 | SFRP1 (0.57) | SFRP1WNT3PTPN2PTPN1 | |
| SCHEMBL4735053 | 0.89 | SFRP1 (0.57) | SFRP1LMNAWNT3 | |
| SCHEMBL4736043 | 0.87 | SFRP1 (0.50) | SFRP1WNT3 | |
| SCHEMBL4785270 | 0.86 | SFRP1 (0.60) | SFRP1WNT3 | |
| SCHEMBL4732857 | 0.85 | SFRP1 (0.71) | SFRP1WNT3 | |
| SCHEMBL4731851 | 0.83 | SFRP1 (0.62) | SFRP1LMNAWNT3 | |
| SCHEMBL4733669 | 0.82 | SFRP1 (0.56) | SFRP1WNT3 | |
| SCHEMBL4735911 | 0.81 | SFRP1 (0.54) | SFRP1WNT3 | |
| SCHEMBL4735525 | 0.81 | SFRP1 (0.61) | SFRP1WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |