Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.40 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | PRKX | P51817 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17545945 | 0.78 | JAK3 (0.73) | JAK3ROCK1ROCK2KCNH2IRAK4 | |
| SCHEMBL15425827 | 0.73 | IRAK4 (0.51) | JAK3IRAK4JAK2JAK1DRD1 | |
| SCHEMBL16764917 | 0.71 | ROCK1 (0.53) | ROCK1ROCK2KCNH2IRAK4CHRNB2 | |
| SCHEMBL16764914 | 0.71 | ROCK1 (0.53) | ROCK1ROCK2KCNH2IRAK4CHRNB2 | |
| SCHEMBL1787658 | 0.69 | CHEK1 (0.42) | ROCK1ROCK2KCNH2CHRNB2CHRNA4 | |
| SCHEMBL15406002 | 0.69 | IRAK4 (0.61) | KCNH2IRAK4JAK2JAK1DRD1 | |
| SCHEMBL15406003 | 0.69 | IRAK4 (0.61) | KCNH2IRAK4JAK2JAK1DRD1 | |
| SCHEMBL16084815 | 0.68 | CHRNB2 (0.48) | ROCK1ROCK2KCNH2IRAK4CHRNB2 | |
| Formic Acid SCHEMBL15406065 | 0.68 | IRAK4 (0.48) | JAK3IRAK4JAK2JAK1DRD1 | |
| Formic Acid SCHEMBL15413427 | 0.68 | IRAK4 (0.48) | JAK3IRAK4JAK2JAK1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008131859-A2 | USE OF CYCLICALLY SUBSTITUTED FUROPYRIMIDINE DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTONIA | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-11-06 | — | — | WO | disclosed |