Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.55 |
| ▸ | NMUR2 | Q9GZQ4 | 4/20 | 0.52 |
| ▸ | NMUR1 | Q9HB89 | 4/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.51 |
| ▸ | CTSL | P07711 | 3/20 | 0.50 |
| ▸ | CTSS | P25774 | 3/20 | 0.50 |
| ▸ | CTSK | P43235 | 3/20 | 0.50 |
| ▸ | CTSH | P09668 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4804787 | 1.00 | APLNR (0.55) | APLNRNMUR2NMUR1OPRM1OPRK1 | |
| SCHEMBL4807604 | 0.95 | APLNR (0.56) | APLNROPRM1OPRK1CXCR4 | |
| SCHEMBL4807584 | 0.95 | APLNR (0.56) | APLNROPRM1OPRK1CXCR4 | |
| SCHEMBL31510401 | 0.90 | APLNR (0.53) | APLNRNMUR2NMUR1OPRM1OPRK1 | |
| SCHEMBL4301705 | 0.90 | MC4R (0.52) | APLNROPRM1OPRK1CTSLCTSS | |
| SCHEMBL30884601 | 0.90 | APLNR (0.58) | APLNRNMUR2NMUR1F2 | |
| SCHEMBL29638078 | 0.89 | APLNR (0.57) | APLNRF2 | |
| SCHEMBL29607754 | 0.89 | APLNR (0.56) | APLNRNMUR2NMUR1OPRM1OPRK1 | |
| SCHEMBL29606819 | 0.89 | APLNR (0.57) | APLNRNMUR2NMUR1OPRM1OPRK1 | |
| SCHEMBL29607035 | 0.89 | APLNR (0.55) | APLNRNMUR2NMUR1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7445903-B2 | Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis | BIOMERIEUX SA (FR) | 2008-11-04 | — | — | US | disclosed |
| US-20070009507-A1 | Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis | UNIVERSITE PAUL SABATIER-TOULOUSE III (FR) | 2007-01-11 | — | — | US | disclosed |
| US-7022485-B1 | Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis | UNIVERSITE PAUL SABATIER (FR) | 2006-04-04 | — | — | US | disclosed |
| EP-1619205-A1 | Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis | Biomerieux (FR) | 2006-01-25 | — | — | EP | disclosed |
| EP-1196450-B1 | FIBRIN CITRULLINE DERIVATIVES AND THEIR USE FOR DIAGNOSING OR TREATING RHEUMATOID ARTHRITIS | BIOMERIEUX SA (FR) | 2005-11-16 | — | — | EP | disclosed |
| EP-1196450-A1 | FIBRIN CITRULLINE DERIVATIVES AND THEIR USE FOR DIAGNOSING OR TREATING RHEUMATOID ARTHRITIS | UNIVERSITE PAUL SABATIER (TOULOUSE III) Etablissement public a caractère scientifique, culturel et professionnel (FR) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001002437-A1 | FIBRIN CITRULLINE DERIVATIVES AND THEIR USE FOR DIAGNOSING OR TREATING RHEUMATOID ARTHRITIS | UNIVERSITE PAUL SABATIER - TOULOUSE III (FR) | 2001-01-11 | — | — | WO | disclosed |