Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.60 |
| ▸ | HTR2C | P28335 | 13/20 | 0.60 |
| ▸ | HTR2B | P41595 | 7/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.60 |
| ▸ | HTR1D | P28221 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | KMO | O15229 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4804854 | 1.00 | HTR2A (0.60) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4808853 | 0.89 | CHRM1 (0.58) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4808865 | 0.89 | CHRM1 (0.58) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL16122626 | 0.87 | CHRM1 (0.61) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4808347 | 0.84 | HTR2A (0.67) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4808355 | 0.84 | HTR2A (0.67) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL16122146 | 0.82 | CHRM1 (0.58) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL16122619 | 0.80 | CHRM1 (0.54) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL763629 | 0.79 | CA12 (0.50) | CHRM1CA12CA1CA2CA7 | |
| SCHEMBL14150020 | 0.77 | CA12 (0.48) | CHRM1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439262-B1 | Substituted 1-alkylamino-1-H-indazoles for the treatment of glaucoma | ALCON, INC. (CH) | 2008-10-21 | — | — | US | claimed |
| US-7439262-B1 | Substituted 1-alkylamino-1-H-indazoles for the treatment of glaucoma | ALCON, INC. (CH) | 2008-10-21 | — | — | US | disclosed |
| US-7338972-B1 | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma | ALCON, INC. (CH) | 2008-03-04 | — | — | US | disclosed |