Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 16/20 | 0.67 |
| ▸ | HTR2C | P28335 | 16/20 | 0.67 |
| ▸ | HTR2B | P41595 | 7/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.67 |
| ▸ | HTR1D | P28221 | 1/20 | 0.67 |
| ▸ | HTR7 | P34969 | 1/20 | 0.67 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.67 |
| ▸ | KMO | O15229 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4808355 | 1.00 | HTR2A (0.67) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4198159 | 0.90 | HTR2A (0.53) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4804854 | 0.84 | HTR2A (0.60) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4804848 | 0.84 | HTR2A (0.60) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL29426218 | 0.83 | PTGER3 (0.51) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL6088764 | 0.80 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL31079586 | 0.80 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4779282 | 0.80 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL475894 | 0.80 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4857914 | 0.79 | HTR2A (0.64) | HTR2AHTR2CHTR2BKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439262-B1 | Substituted 1-alkylamino-1-H-indazoles for the treatment of glaucoma | ALCON, INC. (CH) | 2008-10-21 | — | — | US | disclosed |
| US-7338972-B1 | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma | ALCON, INC. (CH) | 2008-03-04 | — | — | US | disclosed |