Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4810648 | 1.00 | TSHR (0.38) | TSHRTHRBDNM1ATMALDH1A1 | |
| SCHEMBL4820135 | 0.93 | TSHR (0.36) | TSHRTHRBATM | |
| SCHEMBL4816172 | 0.93 | TSHR (0.36) | TSHRTHRBATM | |
| SCHEMBL4812820 | 0.93 | TSHR (0.36) | TSHRTHRBATM | |
| SCHEMBL4812554 | 0.93 | TSHR (0.36) | TSHRTHRBATM | |
| SCHEMBL4815791 | 0.90 | — | — | |
| SCHEMBL6051741 | 0.85 | ATM (0.33) | TSHRATMLMNA | |
| SCHEMBL4808796 | 0.83 | ATM (0.32) | ATM | |
| SCHEMBL4814214 | 0.83 | ATM (0.32) | ATM | |
| SCHEMBL4812988 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1650216-B1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE DIMER OF PHOSPHORUS HETEROCYCLE | NIPPON CHEMICAL IND COMPANY LTD (JP) | 2011-12-28 | — | — | EP | disclosed |
| US-7411096-B2 | Process for producing optically active phosphorus heterocyclic dimer | NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) | 2008-08-12 | — | — | US | disclosed |
| US-20060211888-A1 | 2,2'-bis-(1-alkylphosphetanes); a primary alkyl or cycloalkyl phosphine is reacted with 1,3-dichloropropane, in the presence of n-butyllithium, and then reacted with boron trihydride, oxygen, or sulfur, dimerizing, removing the boron trihydride, oxygen, or sulfur; assymetric hydrogenation catalysts | NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) | 2006-09-21 | — | — | US | disclosed |
| US-20060189818-A1 | Novel optically active phosphorus-chiral diphosphetanes, intermediates of the same, and transition metal complexes containing the diphosphetanes as the ligand | NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) | 2006-08-24 | — | — | US | disclosed |
| EP-1650217-A1 | NOVEL OPTICALLY ACTIVE PHOSPHORUS-CHIRAL DIPHOSPHETANES, INTERMEDIATES OF THE SAME, AND TRANSITION METAL COMPLEXES CONTAINING THE DIPHOSPHETANES AS THE LIGAND | Nippon Chemical Industrial Co., Ltd. (JP) | 2006-04-26 | — | — | EP | disclosed |
| EP-1650216-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE DIMER OF PHOSPHORUS HETEROCYCLE | NIPPON CHEMICAL INDUSTRIAL COMPANY LIMITED (JP) | 2006-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211888-A1 | 2,2'-bis-(1-alkylphosphetanes); a primary alkyl or cycloalkyl phosphine is reacted with 1,3-dichloropropane, in the presence of n-butyllithium, and then reacted with boron trihydride, oxygen, or sulfur, dimerizing, removing the boron trihydride, oxygen, or sulfur; assymetric hydrogenation catalysts | OSBP2, OXSR1, OCIAD2 | TSHR 1687/4885THRB 1015/4885DNM1 494/4885 |
| US-20060189818-A1 | Novel optically active phosphorus-chiral diphosphetanes, intermediates of the same, and transition metal complexes containing the diphosphetanes as the ligand | PHOSPHO1, PLCG1, PLCB1 | TSHR 4032/4885THRB 4151/4885DNM1 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.