OSBP2

Oxysterol-binding protein 2 · Q969R2 · OSBP2 on Sugi Atlas →

23,717 patent compounds predicted against OSBP2, 21,562 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL288274	1.00	4/20
SCHEMBL289034	1.00	4/20
SCHEMBL336387	1.00	4/20
SCHEMBL670025	1.00	4/20
SCHEMBL670026	1.00	4/20
SCHEMBL670744	1.00	4/20
Cholesterol (SCHEMBL2156)	1.00	3/20
Cholesterol (SCHEMBL2157)	1.00	3/20
Cholesterol (SCHEMBL157673)	1.00	3/20
SCHEMBL177267	1.00	3/20
SCHEMBL177268	1.00	3/20
Cholesterol (SCHEMBL255311)	1.00	3/20
Cholesterol (SCHEMBL413494)	1.00	3/20
Cholesterol (SCHEMBL247958)	0.98	3/20
Cholesterol (SCHEMBL335591)	0.98	3/20
Cholesterol (SCHEMBL653608)	0.98	3/20
Cholesterol (SCHEMBL653609)	0.98	3/20
Cholesterol (SCHEMBL720337)	0.98	3/20
Cholesterol (SCHEMBL720339)	0.98	3/20
Cholesterol (SCHEMBL454868)	0.94	3/20

Clinical trials — most relevant to OSBP2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
Smith-Lemli-Opitz Syndrome and Cholic Acid	PHASE1/PHASE2	COMPLETED
Choline Effects - Pre-symptomatic AD	PHASE1	COMPLETED
PBA Use for Treatment of ATF6-/- Patients	EARLY_PHASE1	SUSPENDED
Exome Sequencing in Autistic Spectrum Disorder	nan	COMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
Prospective Genetic Study in Patients With Ovarian Insufficiency	nan	UNKNOWN
Epidemiology of Atherosclerosis	nan	COMPLETED
Genetic Study of Sitosterolemia	nan	COMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI	nan	RECRUITING
Gene Expression in Obesity and Insulin Resistance	nan	COMPLETED
Zinc and the Synthesis of Zinc Binding Proteins (Protocol B)	nan	COMPLETED
Genetic Testing to Understand and Address Renal Disease Disparities	nan	COMPLETED
Genetic, Dietary and Environmental Influences on Vitamin D Metabolism	nan	COMPLETED
LXR and Oocyte Meiosis Resumption	nan	UNKNOWN
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans	nan	UNKNOWN
Immune Cell Response to Stimuli	nan	RECRUITING
Gut Microbiome in Patients With Polycystic Ovary Syndrome	nan	UNKNOWN
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
Study of Changes in Total Cholesterol Levels as a Function of Consuming a Supplement Designed to Improve Cardiovascular Health	nan	UNKNOWN
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)	nan	COMPLETED
Exome Sequencing for Atypical Femoral Fractures	nan	COMPLETED
Cerebellar Mutism Syndrome Study	nan	RECRUITING
A Study to Assess Variation in Potential Biomarkers in Friedreich Ataxia	nan	COMPLETED
The Phenotyping and Genotyping of Taiwanese Patients With Obstructive Sleep Apnea	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a OSBP2 binder may also engage these)

Protein	Name	Similarity
Q5QNQ6	—	0.995	Q5QNQ6 →
Q9BZF3	—	0.993	Q9BZF3 →
Q8K4M9	—	0.991	Q8K4M9 →
P16258	—	0.990	P16258 →
Q8BXR9	—	0.990	Q8BXR9 →
Q8CI95	—	0.989	Q8CI95 →
Q9BXB4	—	0.989	Q9BXB4 →
O54828	—	0.988	O54828 →
S4R1M9	—	0.988	S4R1M9 →
Q9BXB5	—	0.987	Q9BXB5 →
Q3B7Z2	—	0.987	Q3B7Z2 →
Q9BZF2	—	0.986	Q9BZF2 →
Q9ER64	—	0.986	Q9ER64 →
Q62925	—	0.986	Q62925 →
Q9ULM0	—	0.986	Q9ULM0 →
Q5RHD1	—	0.985	Q5RHD1 →
Q9ERS4	—	0.985	Q9ERS4 →
Q68EF0	—	0.985	Q68EF0 →
Q5RD32	—	0.985	Q5RD32 →
O88974	—	0.985	O88974 →
Q07E15	—	0.984	Q07E15 →
Q09YI1	—	0.984	Q09YI1 →
Q8L751	—	0.984	Q8L751 →
Q80TJ7	—	0.984	Q80TJ7 →
Q62136	—	0.984	Q62136 →
Q812E4	—	0.984	Q812E4 →
Q8BMA3	—	0.984	Q8BMA3 →
Q9HB20	—	0.984	Q9HB20 →
Q96SU4	—	0.983	Q96SU4 →
Q9H694	—	0.983	Q9H694 →