Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.65 |
| ▸ | KIT | P10721 | 17/20 | 0.65 |
| ▸ | FLT1 | P17948 | 15/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897420 | 0.85 | KDR (0.89) | KDRKITFLT1 | |
| SCHEMBL4817801 | 0.85 | KDR (0.73) | KDRKITFLT1 | |
| SCHEMBL4818488 | 0.84 | KDR (0.64) | KDRKITFLT1 | |
| SCHEMBL4807676 | 0.79 | KDR (0.64) | KDRKITFLT1 | |
| SCHEMBL4887750 | 0.79 | KDR (0.65) | KDRKITFLT1 | |
| SCHEMBL4818410 | 0.79 | KDR (0.89) | KDRKITFLT1 | |
| SCHEMBL4817603 | 0.79 | KDR (0.64) | KDRKITFLT1 | |
| SCHEMBL4817410 | 0.78 | KDR (0.74) | KDRKITFLT1 | |
| SCHEMBL4817393 | 0.78 | KDR (0.75) | KDRKITFLT1 | |
| SCHEMBL4817039 | 0.78 | KDR (0.89) | KDRKITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468371-B2 | Tricyclic pyrazole kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-12-23 | — | — | US | disclosed |