Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.74 |
| ▸ | KIT | P10721 | 14/20 | 0.74 |
| ▸ | FLT1 | P17948 | 13/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4813450 | 0.91 | KDR (0.71) | KDRKITFLT1 | |
| SCHEMBL4818410 | 0.91 | KDR (0.89) | KDRKITFLT1 | |
| SCHEMBL4817393 | 0.88 | KDR (0.75) | KDRKITFLT1 | |
| SCHEMBL4815775 | 0.87 | KDR (0.72) | KDRKITFLT1 | |
| SCHEMBL4812349 | 0.85 | KDR (0.75) | KDRKITFLT1 | |
| SCHEMBL4817801 | 0.84 | KDR (0.73) | KDRKITFLT1 | |
| SCHEMBL4815369 | 0.83 | KDR (0.64) | KDRKITFLT1 | |
| SCHEMBL4815390 | 0.83 | KDR (0.64) | KDRKITFLT1 | |
| SCHEMBL4887750 | 0.80 | KDR (0.65) | KDRKITFLT1 | |
| SCHEMBL4807660 | 0.78 | KDR (0.65) | KDRKITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468371-B2 | Tricyclic pyrazole kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-20060014816-A1 | Tricyclic pyrazole kinase inhibitors | ABBVIE INC. | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014816-A1 | Tricyclic pyrazole kinase inhibitors | PRKDC, PRKACA, PIK3C3 | KDR 666/4885KIT 472/4885FLT1 850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.