SCHEMBL4807694

SCHEMBL4807694

COc1ccc(-c2nc3cc(Cl)ccc3s2)cc1OC

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.71
SMN1; SMN2 Q16637 5/20 0.53
KDM4E B2RXH2 5/20 0.53
ALDH1A1 P00352 5/20 0.53
MAPT P10636 4/20 0.53
HPGD P15428 3/20 0.53
TP53 P04637 3/20 0.53
HSD17B10 Q99714 3/20 0.53
RAB9A P51151 3/20 0.53
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
MAPK1 P28482 2/20 0.53
NPC1 O15118 2/20 0.53
NPSR1 Q6W5P4 2/20 0.53
GLA P06280 1/20 0.53
GAA P10253 1/20 0.53
PPARG P37231 1/20 0.53
NCOA2 Q15596 1/20 0.53
NCOA1 Q15788 1/20 0.53
HCRTR1 O43613 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15455636 0.88 KDM4E (0.70) AHRSMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL12470894 0.88 KDM4E (0.70) AHRSMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL12471024 0.86 AHR (0.53) AHRSMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL12470462 0.85 SMN1; SMN2 (0.52) AHRSMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL4804932 0.83 AHR (0.71) AHRSMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL30288215 0.83 AHR (1.00) AHRSMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL30307425 0.83 AHR (1.00) AHRSMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL4797786 0.83 AHR (1.00) AHRSMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL12470591 0.83 KDM4E (0.64) SMN1; SMN2KDM4EALDH1A1HPGDRAB9A
SCHEMBL4799251 0.81 KDM4E (0.77) AHRSMN1; SMN2KDM4EALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150366776-A1 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF PUSAN NAT UNIV IND COOP FOUND (KR) 2015-12-24 US disclosed
US-9155690-B2 Compound having skin-whitening, anti-oxidizing and PPAR activities and medical use thereof PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2015-10-13 US disclosed
US-8889881-B2 Compound having skin-whitening, anti-oxidizing and PPAR activities and medical use therefor Pusan National University Industry —University Cooperation Foundation (KR) 2014-11-18 US disclosed
US-20140037564-A1 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR Pusan National University Indusrtyuniversity (KR) 2014-02-06 US disclosed
US-7384966-B2 2-arylbenzothiazole derivatives PHARMINXO LIMITED (GB) 2008-06-10 US disclosed
US-20060063816-A1 2-Arylbenzothiazole derivatives STEVENS MALCOLM F G 2006-03-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150366776-A1 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF PPARG, PPARA, TYR AHR 73/4885SMN1; SMN2 3671/4885KDM4E 3430/4885
US-20140037564-A1 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR PPARG, PPARA, PPARD AHR 65/4885SMN1; SMN2 4087/4885KDM4E 3588/4885
US-20060063816-A1 2-Arylbenzothiazole derivatives CX3CR1, HCN2, CYBB AHR 60/4885SMN1; SMN2 3362/4885KDM4E 4637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.