Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 0.96 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31673207 | 0.78 | GRM5 (0.62) | GRM5CYP1A2KCNH2 | |
| SCHEMBL4862529 | 0.78 | GRM5 (0.62) | GRM5CYP1A2KCNH2 | |
| SCHEMBL31673286 | 0.75 | GRM5 (0.58) | GRM5CYP1A2KCNH2 | |
| SCHEMBL352291 | 0.75 | GRM5 (0.65) | GRM5CYP1A2KCNH2 | |
| SCHEMBL29168747 | 0.74 | GRM5 (0.56) | GRM5CYP1A2KCNH2 | |
| SCHEMBL7419205 | 0.72 | GRM5 (0.54) | GRM5CYP1A2KCNH2 | |
| SCHEMBL4864111 | 0.71 | GRM5 (0.58) | GRM5CYP1A2KCNH2 | |
| SCHEMBL4080 | 0.71 | GRM5 (0.54) | GRM5CYP1A2KCNH2 | |
| SCHEMBL4927688 | 0.71 | GRM5 (0.55) | GRM5CYP1A2KCNH2 | |
| Methyl Alcohol SCHEMBL28902013 | 0.71 | GRM5 (0.67) | GRM5CYP1A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851625-B2 | Process for preparing 2,3-disubstituted indoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-14 | — | — | US | disclosed |
| US-7642352-B2 | Process for preparing 2,3-disubstituted indoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-05 | — | — | US | disclosed |
| US-20090264655-A1 | PROCESS FOR PREPARING 2,3-DISUBSTITUTED INDOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-7408076-B2 | 2-Bromoanaline and 2-chloroaniline compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-7408076-B2 | 2-Bromoanaline and 2-chloroaniline compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-20060287376-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-21 | — | — | US | disclosed |
| EP-1727796-A2 | PALLADIUM CATALYZED INDOLIZATION OF 2-BROMO OR CHLOROANILINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-06 | — | — | EP | disclosed |
| US-7126009-B2 | Palladium catalyzed indolization of 2-bromo or chloroanilines | BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) | 2006-10-24 | — | — | US | disclosed |
| WO-2005090302-A2 | PALLADIUM CATALYZED INDOLIZATION OF 2-BROMO OR CHLOROANILINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-29 | — | — | WO | disclosed |
| US-20050209465-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209465-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | IDO1, IDO2, TDO2 | GRM5 1922/4885CYP1A2 58/4885KCNH2 998/4885 |
| US-20090264655-A1 | PROCESS FOR PREPARING 2,3-DISUBSTITUTED INDOLES | DCLK2, DCLK1, TTL | GRM5 476/4885CYP1A2 1913/4885KCNH2 836/4885 |
| US-20060287376-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | IDO1, IDO2, DRD3 | GRM5 2083/4885CYP1A2 102/4885KCNH2 633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.