Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 14/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 7/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648882 | 0.86 | CXCR2 (0.64) | CXCR2CXCR1CYP2C9SERPINE1ADRA1D | |
| SCHEMBL18953229 | 0.84 | CXCR2 (0.61) | CXCR2CXCR1MAPK10 | |
| SCHEMBL5954904 | 0.80 | CXCR2 (0.75) | CXCR2CXCR1CYP2C9SERPINE1ADRA1D | |
| SCHEMBL4648909 | 0.78 | CXCR2 (0.68) | CXCR2CXCR1CYP2C9SERPINE1ADRA1D | |
| SCHEMBL18953469 | 0.76 | CXCR2 (0.59) | CXCR2CXCR1CYP2C9 | |
| SCHEMBL4686262 | 0.73 | CXCR2 (0.75) | CXCR2CXCR1CYP2C9SERPINE1ADRA1D | |
| SCHEMBL5955072 | 0.73 | CXCR2 (0.47) | CXCR2CXCR1CYP2C9RAB9A | |
| SCHEMBL4687748 | 0.72 | CXCR2 (0.60) | CXCR2CXCR1CYP2C9SERPINE1ADRA1D | |
| SCHEMBL18953404 | 0.71 | CXCR2 (0.45) | CXCR2CXCR1MEN1KMT2AMAPT | |
| SCHEMBL4696544 | 0.71 | CXCR2 (0.48) | CXCR2CXCR1CYP2C9SERPINE1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631559-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1631559-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2005000231-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | disclosed |