Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 8/20 | 0.55 |
| ▸ | PLD2 | O14939 | 8/20 | 0.55 |
| ▸ | PLD1 | Q13393 | 8/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4809038 | 1.00 | CCR1 (0.55) | CCR1PLD2PLD1OPRL1KCNH2 | |
| SCHEMBL4808944 | 0.92 | OPRL1 (0.57) | CCR1PLD2PLD1OPRL1HSD11B1 | |
| SCHEMBL4807964 | 0.91 | PLD2 (0.53) | CCR1PLD2PLD1OPRL1HSD11B1 | |
| SCHEMBL4807955 | 0.91 | PLD2 (0.53) | CCR1PLD2PLD1OPRL1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL4804354 | 0.91 | PLD2 (0.53) | CCR1PLD2PLD1OPRL1HSD11B1 | |
| SCHEMBL4807214 | 0.91 | PLD2 (0.56) | CCR1PLD2PLD1OPRL1HSD11B1 | |
| SCHEMBL4807222 | 0.91 | PLD2 (0.56) | CCR1PLD2PLD1OPRL1HSD11B1 | |
| Hydrochloric Acid SCHEMBL4805706 | 0.91 | OPRL1 (0.56) | CCR1PLD2PLD1OPRL1HSD11B1 | |
| Hydrochloric Acid SCHEMBL4805718 | 0.91 | OPRL1 (0.56) | CCR1PLD2PLD1OPRL1HSD11B1 | |
| SCHEMBL4805869 | 0.91 | PLD2 (0.57) | CCR1PLD2PLD1OPRL1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388020-B2 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2008-06-17 | — | — | US | claimed |
| US-20040116435-A1 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | US | claimed |
| US-7388020-B2 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2008-06-17 | — | — | US | disclosed |
| US-20040116435-A1 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | US | disclosed |
| WO-2002074763-A9 | BENZIMIDAZOL DERIVATIVES MODULATE CHEMOKINE RECEPTORS | ASTRAZENECA AB (SE) | 2002-10-24 | — | — | WO | disclosed |