SCHEMBL4811060

SCHEMBL4811060

COc1ccc(Cc2cc(Cl)ccc2O[C@H]2S[C@@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(OC)c1

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 15/20 0.42
SLC5A1 P13866 12/20 0.42
POLB P06746 1/20 0.36
APLNR P35414 1/20 0.36
CA2 P00918 1/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 1/20 0.35
TDP1 Q9NUW8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4811056 1.00 SLC5A2 (0.42) SLC5A2SLC5A1POLBAPLNRCA2
SCHEMBL4809775 0.84 SLC5A2 (0.38) SLC5A2SLC5A1ALDH1A1
SCHEMBL4809778 0.84 SLC5A2 (0.38) SLC5A2SLC5A1ALDH1A1
SCHEMBL4805362 0.81 SLC5A1 (0.40) SLC5A2SLC5A1
SCHEMBL4815023 0.81 PTGER1 (0.41) SLC5A2SLC5A1
SCHEMBL4805370 0.81 SLC5A1 (0.40) SLC5A2SLC5A1
SCHEMBL4815015 0.81 PTGER1 (0.41) SLC5A2SLC5A1
SCHEMBL4810903 0.80 SLC5A2 (0.41) SLC5A2SLC5A1
SCHEMBL4810911 0.80 SLC5A2 (0.41) SLC5A2SLC5A1
SCHEMBL4812073 0.79 SLC5A2 (0.53) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7414072-B2 Aryl 5-thio-β-d-glucopyranoside derivatives and therapeutic agents for diabetes containing the same TAISHO PHARMACEUTICAL CO., LTD. (JP) 2008-08-19 US disclosed
US-20050209309-A1 Aryl 5-thio-beta-d-glucopyranoside derivatives and remedies for diabetes containing the same TAISHO PHARMACEUTICAL CO., LTD. 2005-09-22 US disclosed
EP-1528066-A1 ARYL 5-THIO-D-GLUCOPYRANOSIDE DERIVATIVES AND REMEDIES FOR DIABETES CONTAINING THE SAME TAISHO PHARMACEUTICAL CO., LTD (JP) 2005-05-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050209309-A1 Aryl 5-thio-beta-d-glucopyranoside derivatives and remedies for diabetes containing the same SLC5A2, SLC5A1, UGGT1 SLC5A2 1/4885SLC5A1 2/4885POLB 4384/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.