Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 8/20 | 0.42 |
| ▸ | SPR | P35270 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4813107 | 1.00 | ALDH1A1 (0.52) | ALDH1A1MAPTHTR2CSPRTSHR | |
| SCHEMBL4813102 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MAPTHTR2C | |
| SCHEMBL6215347 | 0.78 | ALDH1A1 (0.51) | ALDH1A1MAPTHTR2C | |
| SCHEMBL4820539 | 0.77 | HPGD (0.51) | ALDH1A1MAPTHTR2CSPRCYP2D6 | |
| SCHEMBL4820548 | 0.77 | HPGD (0.51) | ALDH1A1MAPTHTR2CSPRCYP2D6 | |
| SCHEMBL4820510 | 0.74 | MAPT (0.43) | ALDH1A1MAPTSPR | |
| SCHEMBL4820519 | 0.74 | MAPT (0.43) | ALDH1A1MAPTSPR | |
| SCHEMBL4815584 | 0.74 | ALDH1A1 (0.68) | ALDH1A1MAPTHSD17B10 | |
| SCHEMBL1574339 | 0.74 | MAPT (0.68) | ALDH1A1MAPTHSD17B10 | |
| SCHEMBL5717553 | 0.73 | ALDH1A1 (0.66) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402606-B2 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-22 | — | — | US | claimed |
| EP-1494663-A1 | DERIVATIVES OF 1-(OXOAMINOACETYL) PENTYLCARBAMATE AS CATHEPSIN K INHIBITORS FOR THE TREATMENT OF BONE LOSS | SmithKline Beecham Corporation (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003086385-A1 | DERIVATIVES OF 1-(OXOAMINOACETYL) PENTYLCARBAMATE AS CATHEPSIN K INHIBITORS FOR THE TREATMENT OF BONE LOSS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-23 | — | — | WO | claimed |
| US-7402606-B2 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-22 | — | — | US | disclosed |