Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.78 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818385 | 0.88 | MET (1.00) | METKITFLT3KDREGFR | |
| SCHEMBL4772466 | 0.83 | MET (0.80) | METFLT3KDR | |
| SCHEMBL4820020 | 0.83 | MET (0.86) | METFLT3KDR | |
| SCHEMBL4068304 | 0.83 | MET (0.83) | METFLT3KDR | |
| SCHEMBL4820675 | 0.82 | MET (0.84) | METKITFLT3KDREGFR | |
| SCHEMBL4822627 | 0.82 | MET (0.84) | METKITFLT3KDRLCK | |
| SCHEMBL4821200 | 0.82 | MET (0.84) | METKITFLT3KDRLCK | |
| SCHEMBL4819198 | 0.82 | MET (0.80) | METKITFLT3KDREGFR | |
| SCHEMBL4815436 | 0.81 | MET (0.79) | METKITFLT3KDREGFR | |
| SCHEMBL4820088 | 0.81 | MET (0.79) | METKITFLT3KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439246-B2 | Fused heterocyclic kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-21 | — | — | US | claimed |
| US-7439246-B2 | Fused heterocyclic kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-21 | — | — | US | disclosed |
| US-7173031-B2 | Pyrrolotriazine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-06 | — | — | US | disclosed |