SCHEMBL4813600

SCHEMBL4813600

NC(CC=O)(C(=O)O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.46
TSHR P16473 1/20 0.46
CYP1A2 P05177 4/20 0.43
KMT2A Q03164 2/20 0.43
HTT P42858 1/20 0.43
MEN1 O00255 1/20 0.43
CYP2D6 P10635 1/20 0.43
HIF1A Q16665 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
GRM5 P41594 1/20 0.39
GRM1 Q13255 1/20 0.39
MAPT P10636 1/20 0.38
KCNN4 O15554 1/20 0.38
CYP2C19 P33261 3/20 0.37
KIF11 P52732 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1908316 0.85 ALDH1A1 (0.65) ALDH1A1TSHRCYP1A2KMT2AHTT
SCHEMBL3613086 0.85 ALDH1A1 (0.65) ALDH1A1TSHRCYP1A2KMT2AHTT
SCHEMBL27630546 0.81 KCNN4 (0.51) ALDH1A1TSHRCYP1A2KMT2AHTT
SCHEMBL8905131 0.80 MEN1 (0.47) ALDH1A1CYP1A2KMT2AMEN1GRM5
Hydrochloric Acid SCHEMBL8500969 0.79 KMT2A (0.46) ALDH1A1CYP1A2KMT2AMEN1GRM5
SCHEMBL6701585 0.79 CYP2C19 (0.41) ALDH1A1TSHRCYP1A2KMT2AHTT
SCHEMBL6367583 0.79 CYP2C19 (0.41) ALDH1A1TSHRCYP1A2KMT2AHTT
SCHEMBL8905147 0.79 KMT2A (0.40) ALDH1A1CYP1A2KMT2AMEN1SMN1; SMN2
SCHEMBL1712531 0.78 CYP1A2 (0.47) ALDH1A1TSHRCYP1A2KMT2AHTT
SCHEMBL1081535 0.78 CYP1A2 (0.47) ALDH1A1TSHRCYP1A2KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021133038-A1 NOVEL AMIDE DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF 주식회사 엘지화학 2021-07-01 WO disclosed
CN-109232464-A Oxadiazoles type connexon and its application 上海新理念生物医药科技有限公司 2019-01-18 CN disclosed
WO-2008139941-A1 SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-11-20 WO disclosed
EP-1984355-A2 CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION Takeda Pharmaceutical Company Limited (JP) 2008-10-29 EP disclosed
WO-2007094513-A2 CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-08-23 WO disclosed
CN-1185251-C Novel LHRH-antagonists with improved solubility characteristics ZANTARIS AG (DE) 2005-01-19 CN disclosed
CN-1348462-A Novel LHRH-antagonists with improved solubility characteristics ZANTARIS AG (DE) 2002-05-08 CN disclosed