Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Norelgestromin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 8/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 3/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.74 |
| ▸ | LMNA | P02545 | 6/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.74 |
| ▸ | ESR1 | P03372 | 5/20 | 0.74 |
| ▸ | AR | P10275 | 5/20 | 0.74 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.74 |
| ▸ | SHBG | P04278 | 4/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.73 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.73 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.73 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norelgestromin SCHEMBL3267125 | 1.00 | NR1I2 (1.00) | NR1I2PGRSLC6A4LMNACYP3A4 | |
| Norelgestromin SCHEMBL3163347 | 1.00 | NR1I2 (1.00) | NR1I2PGRSLC6A4LMNACYP3A4 | |
| Norelgestromin SCHEMBL118611 | 1.00 | NR1I2 (1.00) | NR1I2PGRSLC6A4LMNACYP3A4 | |
| Norelgestromin SCHEMBL4814600 | 1.00 | NR1I2 (1.00) | NR1I2PGRSLC6A4LMNACYP3A4 | |
| SCHEMBL14198630 | 0.89 | NR1I2 (0.80) | NR1I2PGRSLC6A4LMNACYP3A4 | |
| SCHEMBL13306245 | 0.88 | NR1I2 (0.78) | NR1I2PGRSLC6A4LMNACYP3A4 | |
| Norgestimate SCHEMBL7532415 | 0.85 | PGR (0.84) | NR1I2PGRSLC6A4LMNACYP3A4 | |
| Levonorgestrel SCHEMBL22364344 | 0.85 | PGR (1.00) | NR1I2PGRSLC6A4LMNACYP3A4 | |
| Levonorgestrel SCHEMBL27597 | 0.85 | PGR (1.00) | NR1I2PGRSLC6A4LMNACYP3A4 | |
| Levonorgestrel SCHEMBL21741985 | 0.85 | PGR (1.00) | NR1I2PGRSLC6A4LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393964-B2 | Process for the preparation of norelgestromin | S.N.I.F.F. ITALIA S.P.A. (IT) | 2008-07-01 | — | — | US | disclosed |
| US-7393964-B2 | Process for the preparation of norelgestromin | S.N.I.F.F. ITALIA S.P.A. (IT) | 2008-07-01 | — | — | US | disclosed |
| EP-1818338-A1 | Process for the preparation of norelgestromin | S.N.I.F.F. Italia S.P.A. (IT) | 2007-08-15 | — | — | EP | disclosed |
| US-20070149812-A1 | Process for the preparation of norelgestromin | S.N.I.F.F. ITALIA S.P.A. (IT) | 2007-06-28 | — | — | US | disclosed |
| US-20070149812-A1 | Process for the preparation of norelgestromin | S.N.I.F.F. ITALIA S.P.A. (IT) | 2007-06-28 | — | — | US | disclosed |