Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 12/20 | 0.41 |
| ▸ | MAOB | P27338 | 7/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4815489 | 0.83 | PBRM1 (0.49) | PBRM1HRH3IL4I1ACHEMAOB | |
| SCHEMBL1512782 | 0.81 | PBRM1 (0.53) | PBRM1HRH3IL4I1MAOBMAOA | |
| SCHEMBL26703825 | 0.81 | PBRM1 (0.53) | PBRM1HRH3IL4I1MAOBMAOA | |
| SCHEMBL8688671 | 0.78 | PBRM1 (0.50) | PBRM1HRH3IL4I1MAOBMAOA | |
| SCHEMBL26188344 | 0.78 | HRH3 (0.50) | HRH3ACHEMAOBMAOAHTR1A | |
| SCHEMBL3839761 | 0.75 | PBRM1 (0.47) | PBRM1HRH3IL4I1MAOBMAOA | |
| SCHEMBL31660699 | 0.74 | PBRM1 (0.58) | PBRM1HRH3IL4I1MAOBMAOA | |
| SCHEMBL7605245 | 0.74 | PBRM1 (0.53) | PBRM1HRH3IL4I1MAOBMAOA | |
| SCHEMBL4818350 | 0.74 | PBRM1 (0.58) | PBRM1HRH3IL4I1MAOBMAOA | |
| SCHEMBL11778412 | 0.74 | ALDH1A1 (0.51) | HRH3ACHEMAOBMAOAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740579-B1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2015-08-19 | — | — | EP | disclosed |
| US-7468371-B2 | Tricyclic pyrazole kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-20060014816-A1 | Tricyclic pyrazole kinase inhibitors | ABBVIE INC. | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014816-A1 | Tricyclic pyrazole kinase inhibitors | PRKDC, PRKACA, PIK3C3 | PBRM1 988/4885HRH3 2235/4885IL4I1 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.