Sugi Predict

Sugi Predict / Compounds / SCHEMBL4815722

SCHEMBL4815722

SCHEMBL4815722

CC(C)(C)c1cccc(NC(=O)C(C(N)=O)c2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1

nearest known ligand 0.53

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ FLT3 P36888 1/20 0.53
▸ MET P08581 17/20 0.51
▸ BRAF P15056 2/20 0.51
▸ KDR P35968 1/20 0.51
▸ MAPK14 Q16539 1/20 0.51
▸ TNNI3K Q59H18 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4822297 0.88 MET (0.59) MET
SCHEMBL4820065 0.88 MET (0.55) FLT3METKDR
SCHEMBL4814708 0.86 MET (0.54) FLT3METBRAFKDRMAPK14
SCHEMBL4820160 0.86 MET (0.53) FLT3MET
SCHEMBL4820012 0.86 MET (0.61) FLT3METKDR
SCHEMBL4820846 0.85 MET (0.51) FLT3METKDR
SCHEMBL4819186 0.85 MET (0.56) FLT3METKDR
SCHEMBL4818108 0.85 MET (0.52) MET
SCHEMBL4818374 0.85 MET (0.67) FLT3METKDR
SCHEMBL4814790 0.85 MET (0.57) FLT3METKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7439246-B2 Fused heterocyclic kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2008-10-21 — — US claimed
US-7439246-B2 Fused heterocyclic kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2008-10-21 — — US disclosed
US-7173031-B2 Pyrrolotriazine kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2007-02-06 — — US disclosed