Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 6/20 | 0.55 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702279 | 0.86 | TNK2 (0.49) | TNK2JAK3CDK4CCND1BTK | |
| SCHEMBL2953363 | 0.81 | TNK2 (0.64) | TNK2STAT6BRD4FGFR4PTK2 | |
| SCHEMBL30338621 | 0.71 | TNK2 (1.00) | TNK2STAT6BRD4JAK3BTK | |
| SCHEMBL3139892 | 0.69 | TNK2 (0.77) | TNK2EGFRJAK3CDK4CCND1 | |
| SCHEMBL2952193 | 0.67 | TNK2 (0.64) | TNK2BRD4FGFR4JAK2JAK3 | |
| SCHEMBL2949395 | 0.67 | TNK2 (0.60) | TNK2JAK3BTKKDR | |
| SCHEMBL265103 | 0.62 | BRD4 (0.48) | BRD4CDK4CCND1TTK | |
| Hydrochloric Acid SCHEMBL266885 | 0.62 | CDK4 (0.49) | BRD4PTK2EGFRJAK2JAK3 | |
| SCHEMBL30620426 | 0.62 | MAPT (0.64) | BRD4PTK2EGFRJAK2JAK3 | |
| SCHEMBL264449 | 0.61 | BRD4 (0.56) | BRD4EGFRJAK2JAK3CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926734-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS | Amgen Inc. (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007024680-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS | AMGEN INC. (US) | 2007-03-01 | — | — | WO | disclosed |