Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 11/20 | 0.49 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4815958 | 0.86 | TNK2 (0.55) | TNK2BTKKDRJAK3CDK4 | |
| SCHEMBL2949395 | 0.77 | TNK2 (0.60) | TNK2KCNH3USP2LCKBTK | |
| SCHEMBL4701225 | 0.70 | TNK2 (0.49) | TNK2ALOX15ALDH1A1KDM4EMEN1 | |
| SCHEMBL30339004 | 0.66 | TNK2 (1.00) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2953363 | 0.66 | TNK2 (0.64) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2955963 | 0.63 | TNK2 (0.70) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2952115 | 0.61 | WEE1 (0.57) | TNK2USP2MEN1TSHRKMT2A | |
| SCHEMBL3041197 | 0.59 | TNK2 (0.46) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2958052 | 0.58 | TNK2 (0.84) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL30338409 | 0.58 | TNK2 (0.84) | TNK2LCKBTKKDRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926734-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS | Amgen Inc. (US) | 2008-06-04 | — | — | EP | claimed |
| WO-2007024680-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS | AMGEN INC. (US) | 2007-03-01 | — | — | WO | claimed |