Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.81 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.71 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4815842 | 0.95 | CHEK1 (0.85) | CHEK1PDGFRBAURKANTRK1KDR | |
| SCHEMBL4815086 | 0.90 | CHEK1 (1.00) | CHEK1PDGFRB | |
| SCHEMBL4819436 | 0.89 | CHEK1 (0.74) | CHEK1AURKANTRK1KDRAURKB | |
| SCHEMBL4810301 | 0.88 | CHEK1 (1.00) | CHEK1PDGFRB | |
| SCHEMBL4814924 | 0.87 | CHEK1 (0.72) | CHEK1AURKANTRK1KDRAURKB | |
| SCHEMBL4813886 | 0.87 | CHEK1 (0.81) | CHEK1PDGFRB | |
| SCHEMBL4814981 | 0.87 | CHEK1 (1.00) | CHEK1AURKANTRK1KDRAURKB | |
| SCHEMBL4812074 | 0.87 | CHEK1 (1.00) | CHEK1AURKANTRK1KDRAURKB | |
| SCHEMBL4817551 | 0.85 | CHEK1 (0.72) | CHEK1AURKANTRK1KDRAURKB | |
| SCHEMBL6961118 | 0.84 | CHEK1 (0.80) | CHEK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | claimed |
| US-7320986-B2 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBOTT LABORTORIES (US) | 2008-01-22 | — | — | US | disclosed |
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | TK1, MAP3K19, MAP3K20 | CHEK1 73/4885PDGFRB 871/4885AURKA 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.