Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4821619 | 0.67 | CLK4 (0.36) | CLK4DYRK1A | |
| SCHEMBL4819292 | 0.64 | CLK4 (0.36) | CLK4DYRK1A | |
| SCHEMBL677824 | 0.60 | — | — | |
| SCHEMBL9411705 | 0.54 | — | — | |
| SCHEMBL13910997 | 0.54 | CLK4 (0.42) | CLK4DYRK1A | |
| SCHEMBL171853 | 0.53 | HDAC8 (0.47) | CLK4DYRK1A | |
| SCHEMBL153025 | 0.53 | — | — | |
| SCHEMBL28623749 | 0.53 | KDM4E (0.52) | — | |
| SCHEMBL14679265 | 0.52 | CLK4 (1.00) | CLK4DYRK1A | |
| SCHEMBL2309452 | 0.52 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442698-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2008-10-28 | — | — | US | disclosed |
| US-20050026914-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026914-A1 | Substituted heterocyclic compounds and methods of use | NFATC1, ICOS, BET1 | CLK4 3182/4885DYRK1A 2775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.