Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27835324 | 0.96 | DHODH (0.44) | DHODHXDHADORA3ADORA2AADORA2B | |
| SCHEMBL10133074 | 0.89 | NR1H2 (0.44) | XDHCOMTLTA4HNR1H2NR1H3 | |
| SCHEMBL3234188 | 0.83 | NPC1 (0.48) | LTA4HNR1H2NR1H3POLBNPC1 | |
| SCHEMBL27835293 | 0.83 | BRS3 (0.41) | XDHLTA4HNR1H2NR1H3POLB | |
| SCHEMBL14732767 | 0.82 | ADORA1 (0.51) | DHODHADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL3856407 | 0.82 | NR1H2 (0.50) | XDHLTA4HNR1H2NR1H3POLB | |
| SCHEMBL6565202 | 0.79 | DHODH (0.42) | DHODHXDHADORA3ADORA2AADORA2B | |
| SCHEMBL4819873 | 0.79 | DHODH (0.42) | DHODHXDHADORA3ADORA2AADORA2B | |
| SCHEMBL2868814 | 0.79 | HRH3 (0.41) | COMTNR1H2NR1H3NPC1RAB9A | |
| SCHEMBL2872354 | 0.79 | NR1H2 (0.49) | NR1H2NR1H3NPC1RAB9AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402602-B2 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) (FR) | 2008-07-22 | — | — | US | claimed |
| US-20070099975-A1 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) | 2007-05-03 | — | — | US | claimed |
| US-7157483-B2 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2007-01-02 | — | — | US | claimed |
| US-20060069146-A1 | Imidazole derivatives modulating the sodium channels | SCRAS | 2006-03-30 | — | — | US | claimed |
| EP-1401432-B1 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOD CONSEILS RECH APPLIC (FR) | 2005-09-14 | — | — | EP | claimed |
| JP-2005500297-A | — | — | 2005-01-06 | — | — | JP | claimed |
| EP-1401432-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2004-03-31 | — | — | EP | claimed |
| WO-2002102375-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.) (FR) | 2002-12-27 | — | — | WO | claimed |
| US-7402602-B2 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) (FR) | 2008-07-22 | — | — | US | disclosed |
| US-20070099975-A1 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) | 2007-05-03 | — | — | US | disclosed |
| US-7157483-B2 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2007-01-02 | — | — | US | disclosed |
| US-20060069146-A1 | Imidazole derivatives modulating the sodium channels | SCRAS | 2006-03-30 | — | — | US | disclosed |
| EP-1401432-B1 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOD CONSEILS RECH APPLIC (FR) | 2005-09-14 | — | — | EP | disclosed |
| US-20040198792-A1 | Imidazole derivatives modulating the sodium channels | IPSEN PHARMA S.A.S. (FR) | 2004-10-07 | — | — | US | disclosed |
| EP-1401432-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002102375-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.) (FR) | 2002-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198792-A1 | Imidazole derivatives modulating the sodium channels | SCN1A, SCN1B, TRPV1 | DHODH 3332/4885XDH 3748/4885ADORA3 582/4885 |
| US-20070099975-A1 | Imidazole derivatives modulating the sodium channels | SCN2B, KCNJ2, SCN1B | DHODH 2672/4885XDH 2382/4885ADORA3 855/4885 |
| US-20060069146-A1 | Imidazole derivatives modulating the sodium channels | SCN1B, SCN1A, SCN2B | DHODH 1715/4885XDH 1462/4885ADORA3 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.