Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 11/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4819873 | 1.00 | DHODH (0.42) | DHODHALOX5APXDHS1PR1S1PR3 | |
| SCHEMBL4814638 | 0.87 | ALOX5AP (0.44) | DHODHALOX5APXDHS1PR1S1PR3 | |
| SCHEMBL4822860 | 0.86 | ALDH1A1 (0.36) | XDHADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL4817896 | 0.79 | DHODH (0.43) | DHODHXDHS1PR1ADORA3ADORA2A | |
| SCHEMBL4822648 | 0.76 | MAOA (0.41) | ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL27835324 | 0.75 | DHODH (0.44) | DHODHALOX5APXDHS1PR1ADORA3 | |
| SCHEMBL1335887 | 0.73 | TAAR1 (0.50) | ADORA2AADORA1LMNAALBESR1 | |
| SCHEMBL1696579 | 0.72 | ADORA1 (0.47) | ADORA3ADORA2AADORA2BADORA1LMNA | |
| SCHEMBL13527494 | 0.72 | DHODH (0.56) | DHODHXDHADORA3ADORA2AADORA2B | |
| SCHEMBL14732767 | 0.71 | ADORA1 (0.51) | DHODHADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401432-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002102375-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.) (FR) | 2002-12-27 | — | — | WO | disclosed |