Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818548 | 1.00 | MEN1 (0.59) | MEN1KMT2AHDAC4HDAC1CYP2D6 | |
| SCHEMBL4818889 | 1.00 | MEN1 (0.59) | MEN1KMT2AHDAC4HDAC1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4819636 | 0.99 | MEN1 (0.58) | MEN1KMT2AHDAC4HDAC1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4820198 | 0.99 | MEN1 (0.58) | MEN1KMT2AHDAC4HDAC1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4814140 | 0.99 | MEN1 (0.58) | MEN1KMT2AHDAC4HDAC1CYP2D6 | |
| SCHEMBL13316842 | 0.83 | MEN1 (0.69) | MEN1KMT2ACYP2D6SLC6A4SLC6A3 | |
| SCHEMBL4812111 | 0.83 | KMT2A (0.52) | MEN1KMT2ASLC6A4SLC6A3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4810240 | 0.82 | KMT2A (0.51) | MEN1KMT2ASLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL13150333 | 0.81 | HDAC4 (0.49) | MEN1KMT2AHDAC4HDAC1CYP2D6 | |
| SCHEMBL13150096 | 0.81 | ALDH1A1 (0.56) | MEN1KMT2AHDAC4HDAC1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332495-B2 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | NHWA PHARMA. CORPORATION (CN) | 2008-02-19 | — | — | US | claimed |
| US-20060148811-A1 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2006-07-06 | — | — | US | claimed |
| US-7332495-B2 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | NHWA PHARMA. CORPORATION (CN) | 2008-02-19 | — | — | US | disclosed |
| US-20060148811-A1 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148811-A1 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | AAK1, KCNJ1, KHK | MEN1 4866/4885KMT2A 949/4885HDAC4 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.