Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4822293 | 0.95 | CYP17A1 (0.43) | CYP17A1CA12CA1CA9KMT2A | |
| SCHEMBL2349306 | 0.89 | PDK1 (0.46) | CYP17A1CA12CA1CA9KMT2A | |
| SCHEMBL2347126 | 0.89 | CYP17A1 (0.47) | CYP17A1CA12CA1CA9MAPK14 | |
| SCHEMBL18165108 | 0.85 | CA12 (0.48) | CYP17A1CA12CA1CA9PSMB8 | |
| SCHEMBL5544961 | 0.84 | CYP17A1 (0.61) | CYP17A1KMT2AMAPTALDH1A1PTPN1 | |
| SCHEMBL4315966 | 0.82 | MEN1 (0.59) | CYP17A1KMT2AMAPTALDH1A1PTPN1 | |
| SCHEMBL13586831 | 0.81 | MAPK14 (0.45) | KMT2ACTDSP1MAPK14MAPTALDH1A1 | |
| SCHEMBL4818740 | 0.79 | MAPK14 (0.74) | MAPK14 | |
| SCHEMBL1530721 | 0.79 | CYP17A1 (0.41) | CYP17A1CA1KMT2ACTDSP1MAPT | |
| SCHEMBL507957 | 0.79 | CA12 (0.52) | CYP17A1CA12CA1CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626055-B2 | Biphenyl-carboxamide derivatives and their use as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-01 | — | — | US | disclosed |
| US-7432289-B2 | 5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2008-10-07 | — | — | US | disclosed |
| US-7432289-B2 | 5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2008-10-07 | — | — | US | disclosed |
| US-7432289-B2 | 5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2008-10-07 | — | — | US | disclosed |
| EP-1436272-B1 | BIPHENYLCARBOXYLIC AMIDE DERIVATIVES AS P38 KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-05-07 | — | — | EP | disclosed |
| US-7309800-B2 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2007-12-18 | — | — | US | disclosed |
| US-7309800-B2 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2007-12-18 | — | — | US | disclosed |
| US-7271289-B2 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271289-B2 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-20070142476-A1 | Biphenyl-Derivatives as p38 Kinase Inhibitors | GLAXO GROUP LIMITED | 2007-06-21 | — | — | US | disclosed |
| US-20070105850-A1 | Biphenyl-carboxamide derivatives and their use as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2007-05-10 | — | — | US | disclosed |
| US-20070105860-A1 | Biphenylcarboxylic Amide Derivatives as p38 Kinase Inhibitors | GLAXO GROUP LIMITED | 2007-05-10 | — | — | US | disclosed |
| US-20070105860-A1 | Biphenylcarboxylic Amide Derivatives as p38 Kinase Inhibitors | GLAXO GROUP LIMITED | 2007-05-10 | — | — | US | disclosed |
| EP-1611085-B1 | BIPHENYL-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-02-28 | — | — | EP | disclosed |
| US-7183297-B2 | Biphenyl-derivatives as p38-kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2007-02-27 | — | — | US | disclosed |
| US-7183297-B2 | Biphenyl-derivatives as p38-kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2007-02-27 | — | — | US | disclosed |
| US-20040242868-A1 | 5-acylamino-1,1'-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2004-12-02 | — | — | US | disclosed |
| EP-1435934-A1 | 5'-ACYLAMINO-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032971-A1 | 5’-ACYLAMINO-1,1’-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142476-A1 | Biphenyl-Derivatives as p38 Kinase Inhibitors | MAPK1, MAPKAPK2, MAPK3 | CYP17A1 630/4885CA12 4873/4885CA1 4730/4885 |
| US-20040242868-A1 | 5-acylamino-1,1'-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors | MAPK1, MAP3K1, MAPK7 | CYP17A1 2044/4885CA12 4763/4885CA1 3606/4885 |
| US-20070105860-A1 | Biphenylcarboxylic Amide Derivatives as p38 Kinase Inhibitors | MAPK1, MAPKAPK2, MAPK3 | CYP17A1 1758/4885CA12 4725/4885CA1 4063/4885 |
| US-20070105850-A1 | Biphenyl-carboxamide derivatives and their use as p38 kinase inhibitors | MAPK1, MAPKAPK2, MAP3K8 | CYP17A1 1767/4885CA12 4781/4885CA1 4612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.