Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.75 |
| ▸ | ESR2 | Q92731 | 17/20 | 0.75 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.65 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | PLD2 | O14939 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | C5 | P01031 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9271052 | 0.99 | ESR1 (0.75) | ESR1ESR2ENPP1ENPP3MEN1 | |
| SCHEMBL6171041 | 0.87 | ESR1 (0.61) | ESR1ESR2ENPP1 | |
| SCHEMBL8815725 | 0.87 | ESR1 (0.86) | ESR1ESR2ENPP1ENPP3MEN1 | |
| SCHEMBL8599297 | 0.86 | ESR1 (0.80) | ESR1ESR2ENPP1ENPP3 | |
| SCHEMBL6171306 | 0.86 | ESR1 (0.69) | ESR1ESR2 | |
| SCHEMBL7960395 | 0.86 | ESR1 (0.57) | ESR1ESR2 | |
| SCHEMBL7766213 | 0.86 | ESR1 (0.59) | ESR1ESR2ENPP1ENPP3 | |
| SCHEMBL1665661 | 0.86 | ESR1 (1.00) | ESR1ESR2ENPP1ENPP3MEN1 | |
| SCHEMBL17845083 | 0.85 | ESR1 (0.58) | ESR1ESR2ENPP1ENPP3 | |
| SCHEMBL6596880 | 0.85 | ESR1 (0.57) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375229-B2 | Dihydro-dibenzo[B,E]oxepine based selective estrogen receptor modulators, compositions and methods | ELI LILLY AND COMPANY (US) | 2008-05-20 | — | — | US | disclosed |
| US-7271264-B2 | Pentacyclic oxepines and derivatives thereof, compositions and methods | ELI LILLY AND COMPANY (US) | 2007-09-18 | — | — | US | disclosed |
| EP-1551822-B1 | PENTACYCLIC OXEPINES AND DERIVATIVES THEREOF, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LILLY CO ELI (US) | 2006-12-20 | — | — | EP | disclosed |
| US-7119206-B2 | Derivative of dihydro-dibenzo (a) anthracenes and their use as selective estrogen receptor modulators | ELI LILLY AND COMPANY (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060142267-A1 | DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS | WALLACE OWEN B | 2006-06-29 | — | — | US | disclosed |
| US-7067510-B2 | Dihydro-dibenzo[b,e]oxepine based selective estrogren receptor modulators, compositions and methods | ELI LILLY AND COMPANY (US) | 2006-06-27 | — | — | US | disclosed |
| US-20060122386-A1 | Derivative of dihydro-dibenzo (a) anthracenes and their use as selective estrogen receptor modulators | ELI LILLY AND COMPANY | 2006-06-08 | — | — | US | disclosed |
| EP-1527076-B1 | DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS | LILLY CO ELI (US) | 2005-12-28 | — | — | EP | disclosed |
| US-20050261277-A1 | Pentacyclic oxepines and derivatives thereof, compositions and methods | ELI LILLY AND COMPANY | 2005-11-24 | — | — | US | disclosed |
| US-20050240017-A1 | Dihydro-dibenzo[b,e]oxepine based selective estrogren receptor modulators, compositions and methods | ELI LILLY AND COMPANY | 2005-10-27 | — | — | US | disclosed |
| EP-1493741-A2 | Benzo[b]thiophene compounds, intermediates, processes, compositions and methods | Eli Lilly & Company (US) | 2005-01-05 | — | — | EP | disclosed |
| EP-0826683-B1 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | LILLY CO ELI (US) | 2004-10-06 | — | — | EP | disclosed |
| US-5998442-A | ANTICHOLESTEROL AGENTS | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| US-5728724-A | TREATMENT OF POSTMENOPAUSE SYNDROME, OSTEOPOROSIS, CARDIOVASCULAR DISORDERS AND ESTROGEN DEPENDENT CANCER | ELI LILLY AND COMPANY (US) | 1998-03-17 | — | — | US | disclosed |
| EP-0826683-A1 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1997017069-A1 | METHODS FOR TREATING RESISTANT TUMORS | ELI LILLY AND COMPANY (US) | 1997-05-15 | — | — | WO | disclosed |
| EP-0773217-A1 | Benzothiphene derivatives for treating resistant tumors | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1997006796-A1 | BENZOTHIOPHENE COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-02-27 | — | — | WO | disclosed |
| EP-0759434-A1 | Benzothiophene compounds | ELI LILLY AND COMPANY (US) | 1997-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142267-A1 | DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS | ESR1, GPER1, ESR2 | ESR1 1/4885ESR2 3/4885ENPP1 2687/4885 |
| US-20060122386-A1 | Derivative of dihydro-dibenzo (a) anthracenes and their use as selective estrogen receptor modulators | ESR1, GPER1, ESR2 | ESR1 1/4885ESR2 3/4885ENPP1 2537/4885 |
| US-20050261277-A1 | Pentacyclic oxepines and derivatives thereof, compositions and methods | NR5A1, NR3C2, OXER1 | ESR1 6/4885ESR2 8/4885ENPP1 1821/4885 |
| US-20050240017-A1 | Dihydro-dibenzo[b,e]oxepine based selective estrogren receptor modulators, compositions and methods | OXER1, GPER1, ESR1 | ESR1 3/4885ESR2 4/4885ENPP1 2804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.