Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 16/20 | 0.69 |
| ▸ | F2 | P00734 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | GCGR | P47871 | 1/20 | 0.57 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.57 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.57 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818774 | 0.86 | ESR1 (0.75) | ESR1ESR2 | |
| SCHEMBL6171041 | 0.86 | ESR1 (0.61) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL9271052 | 0.85 | ESR1 (0.75) | ESR1ESR2 | |
| SCHEMBL8023306 | 0.85 | DRD2 (0.56) | ESR1ESR2F2GCGR | |
| SCHEMBL6595547 | 0.83 | ESR1 (0.92) | ESR1ESR2F2 | |
| SCHEMBL6595454 | 0.83 | ESR1 (0.80) | ESR1ESR2F2 | |
| SCHEMBL7936846 | 0.82 | ESR1 (0.98) | ESR1ESR2F2 | |
| SCHEMBL6597972 | 0.82 | ESR1 (0.94) | ESR1ESR2F2 | |
| SCHEMBL6595743 | 0.82 | ESR1 (0.94) | ESR1ESR2F2 | |
| SCHEMBL7960395 | 0.82 | ESR1 (0.57) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027051-B1 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2005-01-05 | — | — | EP | disclosed |
| US-6391901-B1 | Thrombin inhibitors | ELI LILLY AND COMPANY | 2002-05-21 | — | — | US | disclosed |
| US-6288105-B1 | COMPOUNDS SUCH AS (S)-2-(4-((2-AMINO-3-HYDROXY-1-OXOPROPYL)AMINO)PHENYL)-6-HYDRO XY-3-(3-METHOXY-4-(1-PYRROLIDINYLMETHYL)BENZYL)BENZO(B)THIOPHE NE | ELI LILLY AND COMPANY | 2001-09-11 | — | — | US | disclosed |
| US-6284756-B1 | ANTICOAGULANT | ELI LILLY AND COMPANY | 2001-09-04 | — | — | US | disclosed |
| US-6265575-B1 | THROMBIN INHIBITORS | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| US-6251921-B1 | ADMINISTERING THROMBIN INHIBITING DIAMINE COMPOUND TO MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-6025382-A | Antithrombotic diamines | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |