Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 13/20 | 0.38 |
| ▸ | DPP4 | P27487 | 5/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4603591 | 0.82 | DPP4 (0.50) | PREPDPP4DPP8DPP9FAP | |
| SCHEMBL666620 | 0.82 | DPP4 (0.50) | PREPDPP4DPP8DPP9FAP | |
| SCHEMBL666210 | 0.69 | DPP4 (0.53) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL4604986 | 0.69 | DPP4 (0.51) | DPP4DPP8DPP9FAP | |
| SCHEMBL666768 | 0.69 | DPP4 (0.51) | DPP4DPP8DPP9FAP | |
| SCHEMBL666762 | 0.60 | DPP4 (0.55) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL4603612 | 0.60 | DPP4 (0.55) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL4603345 | 0.60 | DPP4 (0.53) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL666318 | 0.60 | DPP4 (0.53) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL4604153 | 0.59 | DPP4 (0.58) | DPP4DPP8DPP9FAPDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314884-B2 | non-insulin dependent diabetes mellitus, and impaired glucose tolerance; dipeptidyl peptidase IV (DPP-IV) inhibitors eg (2S)-1-{[(1S)-2-(5-cyano-2-methyl-indol-1-yl)-1-methyl-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile | HOFFMANN-LA ROCHE INC. (US) | 2008-01-01 | — | — | US | disclosed |