Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 19/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | PLD2 | O14939 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | C5 | P01031 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472971 | 0.86 | ESR1 (0.71) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL4823400 | 0.82 | ESR1 (0.78) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL4826412 | 0.82 | ESR1 (0.55) | ESR1ESR2 | |
| SCHEMBL14503715 | 0.82 | ESR1 (0.65) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL11177438 | 0.81 | ESR1 (0.67) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL4826355 | 0.81 | LTA4H (0.52) | ESR1ESR2 | |
| SCHEMBL8477101 | 0.81 | ESR1 (0.62) | ESR1ESR2 | |
| SCHEMBL1358152 | 0.81 | ESR1 (0.62) | ESR1ESR2 | |
| SCHEMBL6193673 | 0.81 | CHEK2 (0.44) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL7121587 | 0.81 | ESR1 (0.59) | ESR1ESR2MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375229-B2 | Dihydro-dibenzo[B,E]oxepine based selective estrogen receptor modulators, compositions and methods | ELI LILLY AND COMPANY (US) | 2008-05-20 | — | — | US | claimed |
| US-20060142267-A1 | DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS | WALLACE OWEN B | 2006-06-29 | — | — | US | claimed |
| EP-1527076-B1 | DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS | LILLY CO ELI (US) | 2005-12-28 | — | — | EP | claimed |
| US-20050240017-A1 | Dihydro-dibenzo[b,e]oxepine based selective estrogren receptor modulators, compositions and methods | ELI LILLY AND COMPANY | 2005-10-27 | — | — | US | claimed |
| US-7375229-B2 | Dihydro-dibenzo[B,E]oxepine based selective estrogen receptor modulators, compositions and methods | ELI LILLY AND COMPANY (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375229-B2 | Dihydro-dibenzo[B,E]oxepine based selective estrogen receptor modulators, compositions and methods | ELI LILLY AND COMPANY (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375229-B2 | Dihydro-dibenzo[B,E]oxepine based selective estrogen receptor modulators, compositions and methods | ELI LILLY AND COMPANY (US) | 2008-05-20 | — | — | US | disclosed |
| US-20060142267-A1 | DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS | WALLACE OWEN B | 2006-06-29 | — | — | US | disclosed |
| US-7067510-B2 | Dihydro-dibenzo[b,e]oxepine based selective estrogren receptor modulators, compositions and methods | ELI LILLY AND COMPANY (US) | 2006-06-27 | — | — | US | disclosed |
| EP-1527076-B1 | DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS | LILLY CO ELI (US) | 2005-12-28 | — | — | EP | disclosed |
| US-20050240017-A1 | Dihydro-dibenzo[b,e]oxepine based selective estrogren receptor modulators, compositions and methods | ELI LILLY AND COMPANY | 2005-10-27 | — | — | US | disclosed |
| EP-1527076-A1 | DIHYDRO-DIBENZO (B,E) OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS | ELI LILLY AND COMPANY (US) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004009603-A1 | DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS | ELI LILLY AND COMPANY (US) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142267-A1 | DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS | ESR1, GPER1, ESR2 | ESR1 1/4885ESR2 3/4885MEN1 1674/4885 |
| US-20050240017-A1 | Dihydro-dibenzo[b,e]oxepine based selective estrogren receptor modulators, compositions and methods | OXER1, GPER1, ESR1 | ESR1 3/4885ESR2 4/4885MEN1 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.