Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL9297699 | 0.94 | TSHR (0.50) | TSHRMEN1KMT2AHTTTHRB | |
| Butoxyethanol SCHEMBL5926145 | 0.91 | TSHR (0.74) | TSHRMEN1KMT2AHTTTHRB | |
| Propylene Glycol SCHEMBL7873540 | 0.91 | TSHR (0.54) | TSHRMEN1KMT2AHTTTHRB | |
| Propylene Glycol SCHEMBL27921454 | 0.89 | TSHR (0.71) | TSHRMEN1KMT2AHTTTHRB | |
| Propylene Glycol SCHEMBL11467717 | 0.89 | TSHR (0.71) | TSHRMEN1KMT2AHTTTHRB | |
| Propylene Glycol SCHEMBL491420 | 0.89 | TSHR (0.71) | TSHRMEN1KMT2AHTTTHRB | |
| Propylene Glycol SCHEMBL10406157 | 0.89 | TSHR (0.56) | TSHRMEN1KMT2AHTTTHRB | |
| Di(Hydroxyethyl)Ether SCHEMBL1315171 | 0.88 | TSHR (0.53) | TSHRMEN1KMT2AHTTTHRB | |
| Propylene Glycol SCHEMBL7816445 | 0.87 | TSHR (0.44) | TSHRMEN1KMT2AHTTTHRB | |
| Propylene Glycol SCHEMBL22325632 | 0.87 | TSHR (0.48) | TSHRMEN1KMT2AHTTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7374686-B2 | Electrocoat manufacturing process | BASF CORPORATION (US) | 2008-05-20 | — | — | US | disclosed |