Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL9297699 | 0.96 | TSHR (0.50) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL22325632 | 0.96 | TSHR (0.48) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL8957336 | 0.94 | TSHR (0.52) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL10558379 | 0.93 | TSHR (0.50) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL55673 | 0.93 | TSHR (0.61) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL4954281 | 0.93 | TSHR (0.61) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL28125539 | 0.91 | TSHR (0.58) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL3930378 | 0.91 | TSHR (0.58) | TSHRUSP2TDP1HTTMAPT | |
| Di(Hydroxyethyl)Ether SCHEMBL4820677 | 0.91 | TSHR (0.61) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL23159879 | 0.89 | USP2 (0.59) | TSHRUSP2TDP1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316159-B1 | PHOTOSENSITIVE COPOLYMER WITH MALEIC ANHYDRIDE, NORBORNENE ACRYLATE | EVERLIGHT USA, INC. | 2001-11-13 | — | — | US | disclosed |