Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CD44 | P16070 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1327351 | 0.92 | C5AR1 (0.43) | C5AR1LMNAPOLBCD44DHFR | |
| SCHEMBL1327354 | 0.86 | C5AR1 (0.44) | C5AR1LMNAPOLBCD44DHFR | |
| SCHEMBL1329410 | 0.85 | C5AR1 (0.54) | C5AR1LMNAPOLBMEN1KMT2A | |
| SCHEMBL1327978 | 0.84 | PRMT5 (0.43) | C5AR1POLBMEN1KMT2AABCB1 | |
| SCHEMBL1327356 | 0.82 | C5AR1 (0.46) | C5AR1LMNAPOLBCD44MEN1 | |
| SCHEMBL1329650 | 0.81 | LMNA (0.46) | C5AR1LMNAPOLBCD44DHFR | |
| SCHEMBL1327907 | 0.80 | C5AR1 (0.48) | C5AR1LMNAPOLBABCB1KDM4E | |
| SCHEMBL2140546 | 0.78 | PRMT5 (0.43) | C5AR1LMNAPOLBCD44KDM4E | |
| SCHEMBL1329134 | 0.78 | LMNA (0.44) | C5AR1LMNAPOLBCD44DHFR | |
| SCHEMBL4417669 | 0.78 | C5AR1 (0.42) | C5AR1LMNAPOLBCD44DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |