Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4821039 | 0.77 | MCL1 (0.54) | MCL1SLC9A1MAPTMEN1KMT2A | |
| SCHEMBL4821026 | 0.77 | MCL1 (0.54) | MCL1SLC9A1MAPTMEN1KMT2A | |
| SCHEMBL4814546 | 0.74 | TSHR (0.50) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4814966 | 0.72 | HRH4 (0.54) | SLC9A1RAB9ADRD2DRD3CHRNA7 | |
| SCHEMBL2323444 | 0.72 | MCL1 (0.71) | MCL1SLC9A1MAPTMEN1KMT2A | |
| SCHEMBL16599480 | 0.71 | MCL1 (0.76) | MCL1SLC9A1MAPTMEN1KMT2A | |
| SCHEMBL20846381 | 0.71 | MCL1 (0.59) | MCL1SLC9A1MAPTMEN1KMT2A | |
| SCHEMBL6141961 | 0.71 | DRD2 (0.60) | MCL1SLC9A1MAPTMEN1KMT2A | |
| SCHEMBL29944143 | 0.71 | MCL1 (0.59) | MCL1SLC9A1MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28264080 | 0.70 | MCL1 (0.69) | MCL1SLC9A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402606-B2 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-22 | — | — | US | claimed |
| US-7402606-B2 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-22 | — | — | US | disclosed |
| EP-1494663-A1 | DERIVATIVES OF 1-(OXOAMINOACETYL) PENTYLCARBAMATE AS CATHEPSIN K INHIBITORS FOR THE TREATMENT OF BONE LOSS | SmithKline Beecham Corporation (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003086385-A1 | DERIVATIVES OF 1-(OXOAMINOACETYL) PENTYLCARBAMATE AS CATHEPSIN K INHIBITORS FOR THE TREATMENT OF BONE LOSS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-23 | — | — | WO | disclosed |