Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 7/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | PTPRB | P23467 | 4/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1196769 | 1.00 | F11 (0.43) | F11JAK2PTPRBCYP17A1MAPKAPK2 | |
| SCHEMBL1196767 | 0.84 | F11 (0.53) | F11JAK2PTPRBCYP17A1 | |
| SCHEMBL1196626 | 0.81 | F11 (0.49) | F11PTPRBCTSSCTSK | |
| SCHEMBL4790723 | 0.79 | F11 (0.41) | F11JAK2PTPRBCYP17A1CTSS | |
| SCHEMBL1196971 | 0.79 | F11 (0.41) | F11JAK2PTPRBCYP17A1CTSS | |
| SCHEMBL478974 | 0.76 | F11 (0.42) | F11PTPRBCYP17A1 | |
| SCHEMBL1196925 | 0.76 | PTPRB (0.43) | F11PTPRBCYP17A1CTSSCTSK | |
| SCHEMBL4142875 | 0.75 | F11 (0.43) | F11PTPRBCYP17A1CTSSCTSK | |
| SCHEMBL1196625 | 0.74 | F11 (0.69) | F11PTPRB | |
| SCHEMBL478713 | 0.73 | F11 (0.40) | F11PTPRBCYP17A1CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981854-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007070826-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |