Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4948702 | 0.88 | — | — | |
| SCHEMBL21733173 | 0.84 | PNMT (0.33) | PNMTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2318235 | 0.76 | — | — | |
| SCHEMBL1712344 | 0.76 | — | — | |
| SCHEMBL1371426 | 0.76 | — | — | |
| SCHEMBL1875764 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL15232076 | 0.74 | — | — | |
| SCHEMBL2468336 | 0.74 | GAA (0.44) | — | |
| Water SCHEMBL1723549 | 0.74 | GAA (0.44) | — | |
| Hydrochloric Acid SCHEMBL30144072 | 0.73 | PNMT (0.39) | PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899350-A1 | PYRAZOLO Ý3 , 4-D¨AZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007025596-A1 | PYRAZOLO [3 , 4-D] AZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |