Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4825609 | 0.92 | ORAI1 (0.40) | RXRARXRBRXRGGRIN2BGRIN1 | |
| SCHEMBL4825285 | 0.87 | ELANE (0.33) | RXRARXRBRXRGGRIN2BGRIN1 | |
| SCHEMBL4820931 | 0.85 | ELANE (0.36) | RXRARXRBRXRGGRIN2BGRIN1 | |
| SCHEMBL4817629 | 0.85 | MAPK9 (0.35) | GRIN2BGRIN1ELANECNR2MAPK13 | |
| SCHEMBL4817627 | 0.85 | MAPK9 (0.35) | GRIN2BGRIN1ELANECNR2MAPK13 | |
| SCHEMBL4824396 | 0.84 | CPT2 (0.39) | GRIN2BGRIN1ELANEMAPK11MAPK14 | |
| SCHEMBL4819979 | 0.83 | MAPK9 (0.38) | RXRARXRBRXRGGRIN2BGRIN1 | |
| SCHEMBL4826214 | 0.76 | RIPK3 (0.37) | GRIN2BGRIN1ELANEMAPK11MAPK14 | |
| SCHEMBL5791511 | 0.72 | MAPK9 (0.47) | GRIN2BGRIN1ELANEMAPK13RAF1 | |
| SCHEMBL4820890 | 0.71 | MAPK14 (0.42) | GRIN2BGRIN1MAPK13RAF1MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429594-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2008-09-30 | — | — | US | claimed |
| EP-1656366-A1 | SUBSTITUTED PYRIMDINONE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-05-17 | — | — | EP | claimed |
| WO-2005019202-A1 | SUBSTITUTED PYRIMDINONE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2005-03-03 | — | — | WO | claimed |
| US-20050043301-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-02-24 | — | — | US | claimed |
| US-7429594-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429594-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429594-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2008-09-30 | — | — | US | disclosed |
| EP-1656366-A1 | SUBSTITUTED PYRIMDINONE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005019202-A1 | SUBSTITUTED PYRIMDINONE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2005-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043301-A1 | Substituted heterocyclic compounds and methods of use | MYLK2, MYLK, MCL1 | RXRA 1212/4885RXRB 918/4885RXRG 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.