Acetic Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	BTK	Q06187	8/20	0.47

▸	EGFR	P00533	6/20	0.47

▸	JAK3	P52333	5/20	0.46

▸	JAK2	O60674	4/20	0.46

▸	TYK2	P29597	4/20	0.46

▸	JAK1	P23458	2/20	0.46

▸	SRC	P12931	8/20	0.46

▸	IGF1R	P08069	3/20	0.46

▸	LCK	P06239	3/20	0.46

▸	PLK4	O00444	2/20	0.46

▸	MAPK13	O15264	2/20	0.46

▸	PDPK1	O15530	2/20	0.46

▸	DAPK3	O43293	2/20	0.46

▸	ROCK2	O75116	2/20	0.46

▸	PAK4	O96013	2/20	0.46

▸	ABL1	P00519	2/20	0.46

▸	NTRK1	P04629	2/20	0.46

▸	INSR	P06213	2/20	0.46

▸	FYN	P06241	2/20	0.46

▸	CDK1	P06493	2/20	0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acetic Acid SCHEMBL4818871	0.93	AURKA (0.51)	BTKEGFRJAK3JAK2TYK2
Acetic Acid SCHEMBL4827149	0.92	BTK (0.48)	BTKEGFRJAK3JAK2TYK2
Acetic Acid SCHEMBL6430603	0.90	EGFR (0.58)	BTKEGFRJAK3JAK2TYK2
Ammonia Solution, Strong SCHEMBL4820345	0.86	SRC (0.60)	BTKEGFRJAK3JAK2TYK2
Acetic Acid SCHEMBL6430342	0.82	EGFR (0.59)	BTKEGFRJAK3JAK2TYK2
Ammonia Solution, Strong SCHEMBL4818822	0.82	EGFR (0.58)	BTKEGFRJAK3JAK2TYK2
Acetic Acid SCHEMBL7045276	0.82	EGFR (0.62)	BTKEGFRJAK3JAK2TYK2
Acetic Acid SCHEMBL6435380	0.82	EGFR (0.55)	BTKEGFRJAK3JAK2TYK2
Acetic Acid SCHEMBL4821510	0.82	EGFR (0.71)	BTKEGFRJAK3JAK2TYK2
Ammonia Solution, Strong SCHEMBL4828005	0.80	EGFR (0.53)	BTKEGFRJAK3JAK2TYK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7332497-B2	As inhibitors of protein kinases	ABBOTT GMBH & CO KG (DE)	2008-02-19	—	—	US	disclosed
US-20040006083-A1	Pyrazolopyrimidines as therapeutic agents	ABBVIE DEUTSCHLAND GMBH & CO KG (DE)	2004-01-08	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20040006083-A1	Pyrazolopyrimidines as therapeutic agents	DPYD, UGT1A1, ABCB1	BTK 1399/4885EGFR 1992/4885JAK3 1336/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.