Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.53 |
| ▸ | IGF1R | P08069 | 9/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 9/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 8/20 | 0.53 |
| ▸ | BTK | Q06187 | 4/20 | 0.46 |
| ▸ | SRC | P12931 | 7/20 | 0.46 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.44 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | CSK | P41240 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6434071 | 0.89 | EGFR (0.67) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| Ammonia Solution, Strong SCHEMBL4820345 | 0.84 | SRC (0.60) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| Ammonia Solution, Strong SCHEMBL4827467 | 0.83 | EGFR (0.63) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| Ammonia Solution, Strong SCHEMBL4818822 | 0.81 | EGFR (0.58) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4826602 | 0.80 | EGFR (0.65) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| Acetic Acid SCHEMBL4824082 | 0.80 | BTK (0.47) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| Acetic Acid SCHEMBL4818871 | 0.79 | AURKA (0.51) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| Acetic Acid SCHEMBL4827149 | 0.78 | BTK (0.48) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL6430288 | 0.74 | EGFR (0.76) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4819199 | 0.74 | EGFR (0.76) | EGFRIGF1RERBB4ERBB2ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332497-B2 | As inhibitors of protein kinases | ABBOTT GMBH & CO KG (DE) | 2008-02-19 | — | — | US | disclosed |
| US-20040006083-A1 | Pyrazolopyrimidines as therapeutic agents | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006083-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, UGT1A1, ABCB1 | EGFR 1992/4885IGF1R 1680/4885ERBB4 1115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.