SCHEMBL4825804

SCHEMBL4825804

COC(=O)c1cccc(C#N)c1Br

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.47
KDM4E B2RXH2 3/20 0.47
HSD17B10 Q99714 2/20 0.47
LMNA P02545 3/20 0.44
TSHR P16473 2/20 0.44
GAA P10253 2/20 0.43
CFTR P13569 1/20 0.43
SLC6A3 Q01959 1/20 0.43
POLB P06746 1/20 0.42
ATM Q13315 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HPGD P15428 1/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
HTT P42858 1/20 0.40
KMT2A Q03164 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31287979 1.00 ALDH1A1 (0.47) ALDH1A1KDM4EHSD17B10LMNATSHR
SCHEMBL16955242 0.83 TSHR (0.44) ALDH1A1KDM4EHSD17B10LMNATSHR
SCHEMBL16719456 0.83 TSHR (0.44) ALDH1A1KDM4EHSD17B10LMNATSHR
SCHEMBL181067 0.82 ALDH1A1 (0.55) ALDH1A1KDM4EHSD17B10LMNATSHR
SCHEMBL987813 0.82 TSHR (0.57) ALDH1A1KDM4EHSD17B10LMNATSHR
SCHEMBL646271 0.81 ALDH1A1 (0.50) ALDH1A1KDM4EHSD17B10LMNATSHR
SCHEMBL30506574 0.81 ALDH1A1 (0.50) ALDH1A1KDM4EHSD17B10LMNATSHR
SCHEMBL14050225 0.81 ALDH1A1 (0.52) ALDH1A1KDM4EHSD17B10LMNATSHR
SCHEMBL2383149 0.81 CA12 (0.48) ALDH1A1KDM4EHSD17B10LMNATSHR
SCHEMBL1449117 0.81 POLB (0.42) ALDH1A1KDM4ELMNATSHRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105358547-B Phenylpyrazole derivatives as ROCK1 and ROCK2 inhibitor 百时美施贵宝公司 2018-04-03 CN disclosed
CN-107108581-A Tieback benzamide derivatives as potent ROCK inhibitors 百时美施贵宝公司 2017-08-29 CN disclosed
CN-106817899-A Spiroheptane as ROCK inhibitor 百时美施贵宝公司 2017-06-09 CN disclosed
CN-105358547-A Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors BRISTOL MYERS SQUIBB CO 2016-02-24 CN disclosed
US-7442760-B2 Electroactive polymers 3M INNOVATIVE PROPERTIES COMPANY (US) 2008-10-28 US disclosed
US-20080026135-A1 ELECTRON TRANSPORT AGENTS FOR ORGANIC ELECTRONIC DEVICES 3M INNOVATIVE PROPERTIES COMPANY 2008-01-31 US disclosed
US-7271406-B2 Electron transport agents for organic electronic devices 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-09-18 US disclosed
US-7094902-B2 Electroactive polymers 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-08-22 US disclosed
US-20060155106-A1 ELECTROACTIVE POLYMERS 3M INNOVATIVE PROPERTIES COMPANY 2006-07-13 US disclosed
EP-1618169-A1 ELECTRON TRANSPORT AGENTS FOR ORGANIC ELECTRONIC DEVICES 3M Innovative Properties Company (US) 2006-01-25 EP disclosed
EP-1573789-A2 ELECTROACTIVE POLYMERS 3M Innovative Properties Company (US) 2005-09-14 EP disclosed
WO-2004102615-A2 ELECTROACTIVE POLYMERS 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-11-25 WO disclosed
WO-2004096948-A1 ELECTRON TRANSPORT AGENTS FOR ORGANIC ELECTRONIC DEVICES 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-11-11 WO disclosed
US-20040214036-A1 Electron transport agents for organic electronic devices 3M INNOVATIVE PROPERTIES COMPANY 2004-10-28 US disclosed
US-20040062930-A1 Electroactive polymers 3M INNOVATIVE PROPERTIES COMPANY 2004-04-01 US disclosed