Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 6/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.47 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | FES | P07332 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974857 | 0.84 | AURKB (0.64) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL4771754 | 0.83 | TEK (0.41) | AURKBAURKATPX2TEKPDE10A | |
| SCHEMBL973140 | 0.75 | AURKB (0.60) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1265702 | 0.74 | AURKB (0.68) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1264644 | 0.72 | AURKB (0.69) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL12423990 | 0.70 | TEK (0.69) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1266413 | 0.69 | TEK (0.77) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1264901 | 0.69 | TEK (0.70) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1265744 | 0.69 | TEK (0.73) | AURKBAURKATPX2TEKKDR | |
| SCHEMBL1265189 | 0.68 | AURKB (0.70) | AURKBAURKATPX2TEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994030-A1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | Amgen Inc. (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007100646-A1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC. (US) | 2007-09-07 | — | — | WO | disclosed |