Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CD44 | P16070 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2141626 | 0.90 | LMNA (0.39) | LMNACD44KDM4EGAAHTT | |
| SCHEMBL1327766 | 0.90 | LMNA (0.39) | LMNACD44KDM4EGAAHTT | |
| SCHEMBL2140419 | 0.88 | LMNA (0.38) | LMNACD44KDM4EGAAHTT | |
| SCHEMBL4417669 | 0.87 | C5AR1 (0.42) | LMNACD44KDM4EGAAHTT | |
| SCHEMBL1329134 | 0.85 | LMNA (0.44) | LMNACD44KDM4EGAAHTT | |
| SCHEMBL1329650 | 0.83 | LMNA (0.46) | LMNACD44KDM4EGAAHTT | |
| SCHEMBL1329410 | 0.80 | C5AR1 (0.54) | LMNAKDM4EHTTMAPTKMT2A | |
| SCHEMBL1328064 | 0.80 | CYP2A13 (0.39) | LMNAKDM4EGAAHTTC5AR1 | |
| SCHEMBL2142672 | 0.79 | C5AR1 (0.34) | KMT2AC5AR1 | |
| SCHEMBL2142684 | 0.79 | C5AR1 (0.37) | KDM4EMAPTC5AR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |