Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491763 | 0.84 | MET (0.47) | METNPC1CLK1RAB9AOGA | |
| SCHEMBL2493598 | 0.80 | MET (0.50) | MET | |
| SCHEMBL2492886 | 0.76 | MET (0.61) | MET | |
| SCHEMBL2676115 | 0.75 | MET (0.53) | MET | |
| SCHEMBL2495186 | 0.74 | MET (0.46) | METNPC1RAB9A | |
| SCHEMBL2493071 | 0.73 | MET (0.47) | METCHRM4 | |
| SCHEMBL2493568 | 0.73 | MET (0.55) | MET | |
| SCHEMBL2493583 | 0.73 | MET (0.59) | MET | |
| SCHEMBL2495195 | 0.72 | MET (0.60) | MET | |
| SCHEMBL14439068 | 0.71 | MET (0.44) | METCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007075567-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-05 | — | — | WO | disclosed |