Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.65 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.62 |
| ▸ | WNT3A | P56704 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826523 | 1.00 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL4822144 | 0.93 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL4822142 | 0.93 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL8271352 | 0.93 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL8270542 | 0.90 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL4825790 | 0.90 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL4821406 | 0.90 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL4818588 | 0.90 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL4825780 | 0.90 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL4823348 | 0.85 | TSHR (0.50) | PDE4APDE4BPDE4CPDE4DCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470723-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470723-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | PDE4A 2547/4885PDE4B 2484/4885PDE4C 2542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.